Posts
SPLASH
There is an exciting new framework for reference-free genomic discovery called _SPLASH (Statistically Primary aLignment Agnostic Sequence Homing) from the Salzman Lab at Stanford. It’s super cool, and there are...
One-Sided Score Test
For some reason, I have not been able to exactly identify what has been going on in my simulations to lead to the strange distributions. My gut tells me it...
Clustering Stability
My last post related to clustering discussed how to describe a “good” clustering algorithm. One way to measure this is by stability, which I’ll define more rigorously later. The main...
A Score Test Primer
Recently, I’ve been doing a lot of exploring in the literature related to score tests and variance component testing. A few questions have come up regarding how a score test...
Clustering: An Axiomatic Approach
Though the journey to this point is a bit confusing, I have recently become interesting in clustering metrics and evaluation. In this post, I’ll work through a couple papers on...
Generalized Linear Mixed Models: Maximum Likelihood Estimation & Variance Component Testing
This post serves as a general summary of work related to testing and estimation for generalized linear mixed models. We’ll use the $\log(\cdot)$ link function as an example (a Poisson...